Restylane® vs Collagen: Which Dermal Filler is Better?

Restylane® vs Collagen Southington

Not long ago, if you wanted to improve the appearance of your wrinkles, you turned to collagen. However, those days are long gone. With the FDA approval of Restylane® in 2003—a hyaluronic acid injection—collagen is no longer the only option. Now, patients seeking younger-looking skin can opt for an injection that works better, lasts longer, and has fewer side effects. No wonder hyaluronic acid injections are our preferred dermal filler at Re:Nu 180 MedSpa.

How Restylane® and Collagen Work

First, it’s important to understand that Restylane® and collagen are comprised of two completely different substances. Restylane® is made out of hyaluronic acid, which is a natural substance found in your skin that helps it retain moisture and volume. While collagen is also naturally occurring in your body, most collagen dermal fillers are composed of bovine (cow) collagen. For this reason, a skin test is often done a month before the collagen treatment to check for allergic reactions.

When injected, both Restylane® and collagen will plump up the skin at the injection site to diminish the appearance of fine lines and wrinkles. However, Restylane® takes it a step further by also attracting water to the injection area and trapping it, which helps create the natural appearance that the dermal filler is known for.

How Long Restylane® and Collagen Last

Both Restylane® and collagen are temporary dermal fillers. In order to maintain the beautiful results of the injections, you will need to continue receiving treatments at a specific interval. For collagen, you will usually need to get more injections after about three months (note: we do not perform collagen injections at our CT medspa). On the contrary, you can expect Restylane® to last for six to nine months before you need visit our Connecticut medspa for a touchup.

The Side Effects of Restylane® and Collagen

As with all injections, both Restylane® and collagen carry the risk of bruising, redness, swelling, and pain at the injection site. However, collagen also carries a 1-3% risk of an allergic reaction. Some recipients of collagen dermal fillers also report an uneven skin tone. In rare cases, some patients have also ended up with connective tissue disorders (e.g. arthritis, lupus) from bovine collagen injections.

While it’s not a side effect, it is also worth noting that there is an injectable enzyme (hyaluronidase) available for Restylane® that can reverse its effects, just in case you change your mind. With collagen, once it is in, you have to wait for your body to dissolve it.

Restylane® vs Collagen:


It’s easy to see why Restylane® is the superior dermal filler. With fewer side effects, longer lasting results, and a more natural appearance, Restylane® is our dermal filler of choice. To discover if it is right for you, contact us today.